The devices and technology described on this website have not been cleared or approved by the FDA. Their safety and effectiveness have not been established. Not available for sale. All data, simulations, and clinical scenarios shown are for illustrative purposes only and do not represent actual clinical outcomes.
Cartan

AI-Native Arthroplasty

Every year, over 1 million Americans receive a knee replacement.

Nearly all of them lose their ACL — the ligament that makes a knee feel like a knee.
We're changing that.

See How It Works

The Problem

The best knee replacement exists.
Almost no one gets it.

A Bicruciate-Retaining (BCR) knee replacement preserves both the ACL and PCL — giving patients the most stable, natural-feeling knee possible.

But BCR is significantly more complex than conventional TKA. Surgeons must navigate tighter anatomical constraints, perform hybrid measured-resection and gap-balancing techniques, and commit to tibial rotation earlier in the procedure. A poorly balanced BCR risks manipulation under anesthesia, poor satisfaction, and early revision.

Over thousands of cases, expert surgeons develop an intuition for BCR. But the vast majority of orthopedic surgeons will never perform enough BCR procedures to reach that level.

“Optimal ligament balancing for an ACL- and PCL-preserved knee has yet to be defined.”

— De Windt et al., Applied Sciences, 2022

Conventional TKA

  • ACL sacrificed in nearly all procedures
  • PCL sacrificed in ~50% of procedures
  • Forced choice between measured resection or gap balancing
  • ~20% patient dissatisfaction rate

What Cartan Is Building

  • Preserving both ACL and PCL as the design goal
  • AI-guided planning adapted to individual anatomy
  • Instrumented feedback during the procedure
  • Designed to make BCR accessible to more surgeons
Cartan BCR Implant Concept

Design concept — not cleared by FDA

1M+
TKA procedures per year in the US
20-25%
of patients are candidates for BCR
<1%
of TKA cases actually receive BCR
65%
of surgeons willing to consider BCR

What if every surgeon could perform BCR like an expert?

Pre-Operative — Step 1

Build the Digital Twin

AI agents ingest patient imaging and kinematic data to construct a physics-based digital twin — a complete biomechanical model of the patient's knee.

Specimen Data

SpecimenJohn Doe
SexMale
Body PartLower Extremity
Ligament StatusIntact (ACL/PCL)
ROM (measured)14.7° — 137.5°
Quad Force Range84.5 — 632.6 N

Imaging Pipeline

BCR Eligibility94.2%

AI Agent

AI

AI

AI

Processing Summary
Imaging slices443
Mesh triangles52,704
Attachment sites16
Kinematic data pts9,101
Parameters estimated47
Processing time2.4 min
Powered byNVIDIA CosmosMONAIPINNsEHR/FHIR IntegrationDICOM Pipeline

Pre-Operative — Step 2

50-Year Simulation

The AI stack is designed to simulate the post-operative knee across a 50-year horizon — exploring wear, stress, and failure modes before the first incision.

Year 0 (Surgery)Year 25 Post-OpYear 50
Simulated Survivorship
94.2%
at 25 years (BCR) — illustrative
0%Simulated data for demonstration purposes only100%
Peak Stress
44.8 MPa
Safety Factor
2.17×
Loading Cycles
25M
BCR Tibial Tray — Von Mises Stress25yr
Medial↑ Tibial island (preserved)Lateral
Anterior ↑ · Posterior ↓
Low
High
Fatigue Damage Accumulation35.0%
0% (pristine)100% (failure)

Surgeon Parameters

Surgeons review and adjust the proposed plan. Each change triggers an updated simulation with new confidence intervals.

Femoral Rotation3° external
07
Tibial Slope (Medial)5°
010
Tibial Slope (Lateral)3°
010
Coronal Angle-3°
-55
Plan Status
Surgeon-approved with modifications
2 iterations · Last updated 14m ago
Powered byNVIDIA PhysicsNeMoPINNsFEBioJAX/DiffraxMonte Carlo

Intra-Operative

Smart Surgery

AI agents track surgical state in real time, provide precise cutting guidance, dynamically update the plan with intraop data, and verify every step against prescribed thresholds.

Workflow Tracker

Intraop Data Collection
Bone length, hardness, condylar forces through ROM, gap measurements
IM Rod & Cutting Jig
Smart instruments positioned with real-time alignment feedback
Distal Femoral CutIN PROGRESS
AI provides translational and rotational adjustments to cutting jig
Proximal Tibial Cut
Tibial island preserved for ACL attachment — rotation locked in
Trialing & Verification
AI confirms alignment, forces, and kinematics within thresholds
Implant Press-Fit
Final component placement and wound closure

Smart Instruments — Live

Medial Force
42N
Target: 35-50N
Lateral Force
38N
Target: 35-50N
Gap Balance
1.2mm
Target: <2mm
Cut Plane Deviation
0.4°
Target: <1°
PLAN UPDATED

Intraop bone hardness measurement integrated. Confidence interval updated: 97.2% → 98.1% survivorship.

AI Guidance

AI

AI

AI

Seamless Conversion

If the surgeon decides to convert from BCR to CR or UC during the procedure, the AI instantly modifies the surgical plan for seamless transition.

BCR → CRBCR → UC
Powered byReal-time IMU FusionComputer VisionNVIDIA IsaacEdge InferenceForce Sensing

Post-Operative

The Learning Loop

After surgery, AI agents are designed to continue working — collecting outcomes, monitoring for complications, generating PT protocols, and feeding real-world data back into the digital twin.

Patient Recovery Timeline

Forgotten Joint Score (FJS-12)Higher = better (max 100)
30
1 week
45
3 weeks
58
6 weeks
74
3 months
85
6 months
93
1 year
1 week
10°–85°
Initial recovery
3 weeks
5°–95°
Early mobilization
6 weeks
2°–108°
PT progression
3 months
0°–120°
Return to activity
6 months
0°–128°
Near full recovery
1 year
0°–132°
Optimal
📊DIGITAL TWIN FEEDBACK

Post-op data feeds back into the digital twin, enabling comparison between simulated and actual outcomes. Designed to improve with each case.

Illustrative data shown for demonstration purposes

Complication Monitor

Aseptic Loosening1.2%
Infection0.8%
Tibial Island Fracture0.3%
Instability0.5%

All risks below threshold. No intervention needed.

AI Agent

AI

AI

Powered byLongitudinal PRO CollectionHIPAA-Compliant PipelineFederated LearningBayesian Updating

The Vision

Every procedure makes every future procedure better.

Each case generates pre-, intra-, and post-operative data that flows back into the AI stack. De-identified and aggregated, this data continuously improves predictions, surgical plans, and patient outcomes — creating a compounding advantage that deepens with every surgery.

Surgical AI Stack
Thousands of digital twins, one intelligence
Every
Patient gets a digital twin
Pre-op
Simulation before surgery
50yr
Simulation horizon
Continuous learning
Powered byNVIDIA PhysicsNeMoPINNsNVIDIA CosmosMONAIFederated LearningJAXEdge AI

Product Roadmap

Phase 1
BCR Knee
Initial platform
Phase 2
CR & UC Knee
Platform expansion
Phase 3
THA · TSA · TAA
Multi-joint platform

This is what AI-native means.

Not AI-assisted. Not AI-enabled. The implant, the instruments, and the intelligence are co-designed from the ground up — each making the others better.